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Bioinformatic analysis

Data Analysis solution for MSB workflows

MSBiosuite is a cloud-based platform accessible through a web interface for the automated analysis of data generated by the sequencing of libraries obtained with Ampli1™ LowPass Kit, Ampli1™ OncoSeek Panel and DEPArray™ OncoSeek Panel.

MSBiosuite manages your entire workflow from uploading raw data, data processing, to downloading results directly onto your computer, and does not require any bioinformatic skill.

MSBiosuite is only available in Europe.

The software is for research use only (RUO) and is not intended for use in a clinical setting or diagnostic procedures.

PRODUCT LITERATURE DOWNLOAD
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UNIQUE BENEFITS

Easy data processing. Automated analysis of sequencing data generated from Ampli1 and DEPArray NGS kits without the need for bioinformatic skills.
User Friendly. Intuitive user interface and graphical views of results.  
Secure. Two-factor authentication ensures the highest-level of confidentiality. Data are encrypted in transit (TLS) and at rest (AES 256/128)..
Data residency. Processing and storage of genomics data are guaranteed to be in the users’ region of choice.  

 

Available Data Analysis Pipelines

Ampli1 LowPass Pipeline

The analysis pipeline automates analysis of raw sequencing data obtained from libraries produced with Ampli1 LowPass kits (for Illumina and Ion Torrent) and enables simultaneous analysis of multiple single-cell data and generation of copy number profiles.

Samples of interest can be easily selected for visual comparison of multiple copy number profiles. An interactive searchable and zoomable view allows browsing specific genomic regions of interest.

 

Hierarchical clustering helps investigate the relationships between samples and study tumor heterogeneity.

Visual comparison of multiple single cell copy number profiles


Copy number profiles of the selected single cell.

Ampli1 and DEPArray OncoSeek Pipelines

Assay-specific pipelines automatically analyze raw sequencing data from DNA libraries produced with Ampli1 OncoSeek Panel and DEPArray OncoSeek Panel and guarantee highly confident variant calling and focal copy number amplifications in selected target genes.

The list of putative somatic variants with basic annotation are ranked by relevance and the allelic frequencies of each variant and basic annotation are also provided. The copy number amplifications section is available in text format or barchart and displays the copy number amplifications in 19 target genes.

Putative somatic variants list and focal copy number amplifications barchart


Somatic variants list.

Focal amplification/copy gains on AR and FGFR1 genes.

Interpretation Report

For OncoSeek pipelines, optional advanced annotation is available on demand. 

Clinically relevant variants are classified by levels of known significance and layers of diagnostic, prognostic, therapeutic and biomarker evidence are integrated. The research service also incorporates deep scientific analysis of each patient’s molecular data, to help identify and prioritize the best clinical trial options.

How it Works

Sequencing data are uploaded to MSBiosuite by a service connector installed on your computer. After the upload, the raw data become visible on your MSBiosuite account and you can easily select the data to be analyzed in a single run and create a batch. You can then launch the analysis and monitor the status in real time through the web interface. After the analysis, you can browse results online or download a results file to your PC.

EU Product Code Description

CODE
DESCRIPTION
KI0129 (16 samples)
KI0130 (48 samples)
KI0131 (320 samples)
MSBiosuite Ampi1 LowPass Analysis (Ion Torrent)
KI0132 (16 samples)
KI0133 (48 samples)
KI0134 (320 samples)
MSBiosuite Ampi1 LowPass Analysis (Illumina)
KI0138 (9 samples)
KI0139 (24 samples)
KI0140 (120 samples)
MSBiosuite Ampi1 Oncoseek Analysis
KI0135 (9 samples)
KI0136 (24 samples)
KI0137 (120 samples)
MSBiosuite DEPArray OncoSeek Analysis
KI0141
Interpretation Report (available only for OncoSeek panels)